W U Malik Memorial Lecture Series - Department of Chemistry,Indian Institute of Technology Roorkee
W U Malik Memorial Lecture Series

Prof. W U Malik Memorial Lecture Series

Bio sketch of Prof. W. U. Malik

Prof. Wahid Uddin Malik was born on April 16, 1922 at Agra. He received Ph.D. from Agra University in 1948 and D.Sc. from Aligarh Muslim University in 1961. He joined Roorkee University in 1963 as first Professor and Head of the Chemistry Department. Before that, he served as Reader in Aligarh Muslim University. He was elected as Fellow of Royal Society of Chemistry in 1960 and National Academy of Sciences in 1966. He served as Vice-Chancellor of University of Kashmir, Bundelkhand University and Allahabad University. He was instrumental in diversifying teaching and research activities in the department.

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Date: November 25, 2020 (Wednesday)

Time: 06:00 pm (IST)

Speaker: Prof. G. Mugesh

Title: Synthetic Nanozymes for Modulation of Cellular Redox Processes

Abstract: Oxidative stress is caused by an imbalance between the production of reactive oxygen species (ROS) and the biological system's ability to detoxify these reactive intermediates. It is well known that oxidative stress is associated with diverse diseases, including cancer, renal disease, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Antioxidant treatment has been found to be unsuccessful in many cases as they promote disease and increase mortality in humans. The reason for this unexpected behaviour is that antioxidants with strong reducing ability can act as pro-oxidants and increase the oxidative stress. Therefore, it is important to develop antioxidants without pro-oxidant activity. In this regard, our group is working on the design and synthesis of antioxidant enzyme mimetics such as small molecules and nanomaterials that can combat oxidative stress without affecting the cellular antioxidant systems. In this lecture, I will discuss our recent results on the development of nanozymes that can be used for cellular and biomedical applications.

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